![]() ![]() And so the leading strand again, which is highlighted with a yellow background, is moving and being built in the same direction as the replication Fork movement, and that it also applies for this leading strand over here being built in the same direction as the replication fork movement. And this replication for here is moving in towards the right. And there's also going to be a lagging strand which is built in the opposite direction of the replication fork movement and so recall that this replication for here is moving in this direction to the left. Now, each of these replication forks notice that there is a leading strand which is going to be built in the same direction as the replication for movement. And so you can also see the origin of replication here, which is, uh, the sequence of DNA where DNA replication begins. We have one replication fork over here on the left and another replication fork over here on the right. And so notice that here what we're showing you is a replication bubble with two replication forks. And if we take a look at our image down below weaken better distinguish between the leading and lagging DNA strands. These Okazaki fragments are eventually going to be CO violently a Neil to each other by an enzyme called DNA like Jace. Now, these multiple small segments in the lagging DNA strand. And again, the leading strained only requires one RNA primary. And so the lagging DNA strand requires multiple Arna primers. Each of these Okazaki fragments each requires an RNA primer to be built. And because it's built in the opposite direction of the replication fork movement, the lagging strand is replicated in multiple small segments that air called Okazaki fragments, and these Okazaki fragments are named after the Japanese scientists whose last name was Okazaki. Instead, the lagging DNA strand is going to be built with this continuous replication in the opposite direction of the replication fork movement. The lagging DNA strand, on the other hand, is not built with continuous replication. A primer is going to be associated with the leading strand now. And because the leading DNA strand is built in the same direction as the Replication fork movement, it only requires just one single are in a primer, and so that requirement for one single are in. Now the leading DNA strand is going to be built with continuous DNA replication in the same direction as the replication fork movement. The first one will be the leading DNA strand, and the second one will be the lagging DNA strand. And so it turns out that upon separation of DNA during DNA replication at each replication fork, they're going to be two single stranded DNA molecules. DNA polymerase fills in gaps in the lagging strand.In this video, we're going to introduce the leading and lagging DNA strands. Replication of the lagging strand occurs in fragments as the original DNA is unwound. Replication of the leading strand begins near the origin of replication. Replication of the leading strand is continuous. Replication of the lagging strand is discontinuous. Define the characteristics of the leading and lagging strands in the replication bubble. Step 3: Define the terms leading strand, lagging strand, Okazaki fragment, and RNA primer.
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